Preparation, characterization, and photodynamic treatment of toluidine blue PLGA-loaded nanoparticles in Porphyromonas gingivalis

In vivo killing of Porphyromonas gingivalis by toluidine blue-mediated photosensitization in an animal model.

Porphyromonas gingivalis is one of the major causative organisms of periodontitis and has been shown to be susceptible to toluidine blue-mediated photosensitization in vitro. The aims of the present study were to determine whether this technique could be used to kill the organism in the oral cavities of rats and whether this would result in a reduction in the alveolar bone loss characteristic o...

Preparation and characterization of anticancer drug-loaded implantable PLGA microparticles

This article describes the preparation and characterization of anticancer drug-loaded poly(lactide-coglycolide) (PLGA) microparticles. PLGA microparticles loaded with doxorubicin HCl (DOX) were prepared via o/w emulsion solvent evaporation. The release characteristics, encapsulation efficiency, size, and morphology of the PLGA microparticles were also determined. A cytotoxicity test was perform...

Preparation and characterization of Tribulus terrestris-loaded nanoparticles

Background and objectives: Tribulus terrestris is a flowering herb (Zygophyllaceae) with several properties in folk medicine such as diuretic, tonic, aphrodisiac, analgesic, astringent, and stomachic-lithotripter activities. Although, some extracts and phytochemicals represent excellent bio-activity in vitro, less or no in vivo activity is observed du...

Preparation and Characterization of Paclitaxel-loaded PLGA nanoparticles coated with cationic SM5-1 single-chain antibody.

The purpose of this study was to develop paclitaxel-loaded poly(lactide-co-glycolide) (PLGA) nanoparticles coated with cationic SM5-1 single-chain antibody (scFv) containing a polylysine (SMFv-polylys). SM5-1 scFv (SMFv) is derived from SM5-1 monoclonal antibody, which binds to a 230 kDa membrane protein specifically expressed on melanoma, hepatocellular carcinoma and breast cancer cells. SMFv-...

preparation, characterization and cytotoxicity of methotrexate-loaded plga superparamagnetic nanoparticles for theranostics